COVID-19 vaccines remain a key tool to prevent severe cases and deaths from COVID-19 infection. AU Member States should accelerate the immunization of high-risk populations. The presence of EG.5 or the sub-lineages of the coronavirus has been reported in Uganda, Egypt, Cape Verde, and South Africa and Africa CDC is therefore continuing to monitor this new variant in order to fully understand the pathogenicity and its impact on vaccine efficacy in Africa. Is Covid-19 vaccine really helping in preventing infection ?