The WHO says a prequalification process is underway for the R21/Matrix-M vaccine, with a working group of expert advisors reviewing safety and efficacy data from the ongoing phase three trial before making any recommendation. The approval of the R21/Matrix-M malaria vaccine by Ghana and Nigeria is the first time a major malaria intervention has been adopted without World Health Organization (WHO) qualification and could greatly reduce child deaths in Africa, Can the world be malaria free ?