The national health authorities, with support from Africa CDC and other partners, have established an epidemic response mechanism to effectively control any spread of the virus in Guinea and other affected countries. The mandatory 42-day countdown was triggered after the last case tested negative. Today, Equatorial Guinea announced the end of the outbreak of Marburg Virus Disease (MVD) which was confirmed on 13 February 2023 in the north-western part of the country in the province of Kie Ntem. Can a virus be totally eliminated ?